Hydrochloric Acid → HCID 22734135, compound

HRID 1937418Notes

Reaction equation

HRID 1937418 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:27])[C:7]=1[NH:8][C:9]([C:11]1[C:16]2[CH:17]=[C:18]([C:20]([O:22]CC)=[O:21])[O:19][C:15]=2[C:14]([O:25][CH3:26])=[CH:13][CH:12]=1)=[O:10].[OH-].[Na+].Cl>CO>[Cl:27][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[NH:8][C:9]([C:11]1[C:16]2[CH:17]=[C:18]([C:20]([OH:22])=[O:21])[O:19][C:15]=2[C:14]([O:25][CH3:26])=[CH:13][CH:12]=1)=[O:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22460993HCID 22460993, compound

Product 1

HCID 22734135HCID 22734135, compoundYield 98.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 4-[(3,5-dichloro-4-pyridyl)carbamoyl]-7-methoxybenzofuran-2-carboxylate (6.1 g) was dissolved in methanol (80 ml), 1 N aqueous NaOH (40 ml) was added thereto under cooling on ice, and the mixture was returned to room temperature and stirred for 2 hours. The reaction mixture was acidified by dropwise adding 1 N aqueous HCl under cooling on ice, and the precipitated crystals were collected by filtration and washed with water to give Compound K (5.6 g, 98%).

Workup

  1. temperatureunder cooling on ice
  2. customwas returned to room temperature
  3. temperatureunder cooling on ice
  4. filtrationthe precipitated crystals were collected by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-71f53087041a4d23945d7c957fbb662f
Source dataset
uspto-grants-2002_05
Patent number
US06395738B1

Reaction notes

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