Dimethyl 2-(4'-methoxy-3-nitrobiphenyl-4-yl)malonate → 4'-Methoxy-3-nitrobiphenyl-4-acetic acid

HRID 1937515Notes

Reaction equation

HRID 1937515 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH:15](C(OC)=O)[C:16]([O:18]C)=[O:17])=[C:11]([N+:24]([O-:26])=[O:25])[CH:10]=2)=[CH:5][CH:4]=1>Cl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C:16]([OH:18])=[O:17])=[C:11]([N+:24]([O-:26])=[O:25])[CH:10]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 10737157Dimethyl 2-(4'-methoxy-3-nitrobiphenyl-4-yl)malonate

Product 1

HCID 104935034'-Methoxy-3-nitrobiphenyl-4-acetic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Crude dimethyl 4′-methoxy-3-nitro-biphenyl-4-malonate was heated at 100° C. in 60 mL of 6 N hydrochloric acid for 15 hours and cooled. The precipitate was collected by filtration, washed with water and hexane, and dried to give 7.2 g of crude 4′-methoxy-3nitrobiphenyl-4-acetic acid as a light tan solid.

Workup

  1. temperaturecooled
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water and hexane
  4. customdried

Sources & evidence

ORD record
ord-8f00626d9e834c01a3fe25ba2bb5a86f
Source dataset
uspto-grants-2002_05
Patent number
US06395734B1

Reaction notes

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