反应详情

3-(2-carboxyethyl)-2,4-dimethyl-5-formylpyrrole (97.6 mg), 127 mg 6-(3-ethoxyphenyl)-2-oxindole, and 2 drops piperidine in 2 mL ethanol were heated at 90° C. overnight. The reaction mixture was cooled and concentrated. The residue was suspended in 6 N aqueous hydrochloric acid. The precipitate was filtered, washed with water to pH 6 and dried in a vacuum oven overnight to give 227 mg of the title compound (˜100%) as a brown solid.

1. temperatureThe reaction mixture was cooled
2. concentrationconcentrated
3. filtrationThe precipitate was filtered
4. washwashed with water to pH 6
5. customdried in a vacuum oven overnight