Piperidine → HCID 178523006, compound

HRID 1937838Notes

Reaction equation

HRID 1937838 reaction equation
C1CCNCC1.O=C(NCc1ccc(F)cc1)c1nc(Br)c2cccnc2c1O>CC(C)(C)[O-].Cc1ccccc1.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.[Cl][Pd][Cl].[Na+]>O=C(NCc1ccc(F)cc1)c1nc(N2CCCCC2)c2cccnc2c1O

Participants

6

Reactant 2

HCID 8082PiperidineHCID 223464015-bromo-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide

Product 1

HCID 178523006HCID 178523006, compoundYield 15%

Reagents, catalysts & solvents 3

HCID 23676156Sodium t-butoxideReagentHCID 10876480Bis(tri-o-tolylphosphine)palladium(II) DichlorideCatalystHCID 1140TolueneSolvent2×

Conditions

Temperature
100 °C

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-0a4f9a8ce9e24c8eaf5d3e9577c55edd
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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