Piperidine → HCID 178462864, compound

HRID 1937840Notes

Reaction equation

HRID 1937840 reaction equation
C1CCNCC1.CCn1c(=O)c2c(nc(N[C@H]3CCC[C@H]3O)n2Cc2ccc(OC)c(Br)c2)n(CCO)c1=O>CC(C)(C)[O-].Cc1ccccc1.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.[Cl][Pd][Cl].[Na+]>CCn1c(=O)c2c(nc(N[C@H]3CCC[C@H]3O)n2Cc2ccc(OC)c(N3CCCCC3)c2)n(CCO)c1=O

Participants

6

Reactant 2

HCID 8082PiperidineHCID 129360362HCID 129360362, compound

Product 1

HCID 178462864HCID 178462864, compoundYield 41%

Reagents, catalysts & solvents 3

HCID 23676156Sodium t-butoxideReagentHCID 10876480Bis(tri-o-tolylphosphine)palladium(II) DichlorideCatalystHCID 1140TolueneSolvent2×

Conditions

Temperature
100 °C

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-cec984eb3c364f3ea6aa04a9719cdf56
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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