Piperidine → HCID 178474765, compound

HRID 1937862Notes

Reaction equation

HRID 1937862 reaction equation
C1CCNCC1.CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(Cl)c(C)cc21>CC(C)(C)[O-].CC(C1=C(P(C2CCCCC2)C2CCCCC2)C=C[CH]1)P(C(C)(C)C)C(C)(C)C.COCCOC.[CH]1C=CC=C1.[Fe].[Na+]>CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(N3CCCCC3)c(C)cc21

Participants

6

Reactant 2

HCID 8082PiperidineHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

Product 1

HCID 178474765HCID 178474765, compoundYield 53%

Reagents, catalysts & solvents 3

HCID 23676156Sodium t-butoxideReagentHCID 178437370HCID 178437370, compoundCatalystHCID 80711,2-DimethoxyethaneSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-a1f856b8caff48d8993fa0e3a97e9c75
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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