Piperidine → HCID 138973475, compound

HRID 1937863Notes

Reaction equation

HRID 1937863 reaction equation
C1CCNCC1.O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1>CC(C)(C)[O-].CC(C1=C(P(C2CCCCC2)C2CCCCC2)C=C[CH]1)P(C(C)(C)C)C(C)(C)C.COCCOC.[CH]1C=CC=C1.[Fe].[Na+]>O=C1Nc2ccc(N3CCCCC3)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1

Participants

6

Reactant 2

HCID 8082PiperidineHCID 64139Efavirenz

Product 1

HCID 138973475HCID 138973475, compoundYield 4%

Reagents, catalysts & solvents 3

HCID 23676156Sodium t-butoxideReagentHCID 178437370HCID 178437370, compoundCatalystHCID 80711,2-DimethoxyethaneSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-0d9b7c7bb75b4ec1832558eca4544b82
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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