Piperidine → HCID 178500184, compound

HRID 1937882Notes

Reaction equation

HRID 1937882 reaction equation
C1CCNCC1.COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1>C=CCc1ccccc1.CC(C)(C)[O-].CC(C)c1cccc(C(C)C)c1-n1ccn(-c2c(C(C)C)cccc2C(C)C)[c]1=[Pd][Cl].COCCOC.[K+]>COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(N2CCCCC2)cc1

Participants

6

Reactant 2

HCID 8082PiperidineHCID 15225389Methyl 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoate

Product 1

HCID 178500184HCID 178500184, compoundYield 40%

Reagents, catalysts & solvents 3

HCID 23665647Potassium tert-butoxideReagentHCID 178438929HCID 178438929, compoundCatalystHCID 80711,2-DimethoxyethaneSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-14a0b29ffff5402ca626c8e9abaae090
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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