6-Bromoindole → HCID 178527309, compound

HRID 1937974Notes

Reaction equation

HRID 1937974 reaction equation
Brc1ccc2cc[nH]c2c1.CC1(C)OB(c2cn(S(=O)(=O)c3ccccc3)c3ncccc23)OC1(C)C>COCCOC.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>O=S(=O)(c1ccccc1)n1cc(-c2ccc3cc[nH]c3c2)c2cccnc21

Participants

8

Reactant 2

HCID 6764936-BromoindoleHCID 455881371-(Phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine

Product 1

HCID 178527309HCID 178527309, compoundYield 46%

Reagents, catalysts & solvents 5

HCID 10340Sodium CarbonateReagentHCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 962WaterSolventHCID 80711,2-DimethoxyethaneSolvent2×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
85 °C

Workup

  1. stirringNo procedure recorded

Sources & evidence

ORD record
ord-2fce4bd01b29465298c19598602adfb3
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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