6-Bromoindole → HCID 178420023, compound

HRID 1937979Notes

Reaction equation

HRID 1937979 reaction equation
Brc1ccc2cc[nH]c2c1.CC1(C)OB(c2ccc(Nc3nc4ccccc4s3)cc2)OC1(C)C>COCCOC.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>c1ccc2sc(Nc3ccc(-c4ccc5cc[nH]c5c4)cc3)nc2c1

Participants

8

Reactant 2

HCID 6764936-BromoindoleHCID 22347024N-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzo[d]thiazol-2-amine

Product 1

HCID 178420023HCID 178420023, compoundYield 32%

Reagents, catalysts & solvents 5

HCID 10340Sodium CarbonateReagentHCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 962WaterSolventHCID 80711,2-DimethoxyethaneSolvent2×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
85 °C

Workup

  1. stirringNo procedure recorded

Sources & evidence

ORD record
ord-dc227a13526a4483a83378c2d258236b
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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