6-Bromoindole → HCID 178432497, compound

HRID 1937981Notes

Reaction equation

HRID 1937981 reaction equation
Brc1ccc2cc[nH]c2c1.Cc1nc(-c2cccc(B3OC(C)(C)C(C)(C)O3)c2)no1>COCCOC.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>Cc1nc(-c2cccc(-c3ccc4cc[nH]c4c3)c2)no1

Participants

8

Reactant 2

HCID 6764936-BromoindoleHCID 532171565-Methyl-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,2,4-oxadiazole

Product 1

HCID 178432497HCID 178432497, compoundYield 40%

Reagents, catalysts & solvents 5

HCID 10340Sodium CarbonateReagentHCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 962WaterSolventHCID 80711,2-DimethoxyethaneSolvent2×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
85 °C

Workup

  1. stirringNo procedure recorded

Sources & evidence

ORD record
ord-a534e92de3004350b8ff2483c2b18516
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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