6-Bromoindole → HCID 178521688, compound

HRID 1937995Notes

Reaction equation

HRID 1937995 reaction equation
Brc1ccc2cc[nH]c2c1.CC1(C)OB(c2cccc(C3(NC(=O)OCc4ccccc4)CC3)c2)OC1(C)C>COCCOC.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>O=C(NC1(c2cccc(-c3ccc4cc[nH]c4c3)c2)CC1)OCc1ccccc1

Participants

8

Reactant 2

HCID 6764936-BromoindoleHCID 129952385Benzyl (1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropyl)carbamate

Product 1

HCID 178521688HCID 178521688, compoundYield 40%

Reagents, catalysts & solvents 5

HCID 10340Sodium CarbonateReagentHCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 962WaterSolventHCID 80711,2-DimethoxyethaneSolvent2×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
85 °C

Workup

  1. stirringNo procedure recorded

Sources & evidence

ORD record
ord-7db9f909fefe446dafdaa9398b3dff68
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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