6-Bromoindole → HCID 178519849, compound

HRID 1937996Notes

Reaction equation

HRID 1937996 reaction equation
Brc1ccc2cc[nH]c2c1.CC1(C)OB(c2ccc3[nH]cc(C(=O)[C@H]4CCCN4C(=O)OCc4ccccc4)c3c2)OC1(C)C>COCCOC.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>O=C(c1c[nH]c2ccc(-c3ccc4cc[nH]c4c3)cc12)[C@H]1CCCN1C(=O)OCc1ccccc1

Participants

8

Reactant 2

HCID 6764936-BromoindoleHCID 178431022HCID 178431022, compound

Product 1

HCID 178519849HCID 178519849, compoundYield 24%

Reagents, catalysts & solvents 5

HCID 10340Sodium CarbonateReagentHCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 962WaterSolventHCID 80711,2-DimethoxyethaneSolvent2×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
85 °C

Workup

  1. stirringNo procedure recorded

Sources & evidence

ORD record
ord-b422a0d48de24beabeeb82ddbd8adc33
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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