Hydrogen Bromide → Ethyl 2-bromo-1,3-thiazole-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

A solution of 30 g (174.3 mmol) ethyl-2-aminothiazole-4-carboxylate [prepared as in Example 1a)] in a mixture of 100 ml HBr (65%) and 100 ml of water was cooled to -15° C. and a solution of 12.03 g (174.3 mmol) sodium nitrite in 40 ml water was added over a period of 30 minutes and the mixture stirred for another 30 minutes at -15° C. After warming to room temperature, the solid was collected, washed with 50 ml cold water and dried to give 23.7 g (57.6%) ethyl-2-bromothiazole-4-carboxylate m.p. 63°-65° C.

Provenance & Evidence