3-Nitro-7-(2-trifluoromethylbenzyloxy)quinoline → 3-Amino-7-(2-trifluoromethylbenzyloxy)quinoline

HRID 1938336Notes

Reaction equation

HRID 1938336 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]([F:25])([F:24])[F:23])[CH:8]=2)([O-])=O>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]([F:25])([F:23])[F:24])[CH:8]=2

Participants

4

Reactant 1

HCID 214693273-Nitro-7-(2-trifluoromethylbenzyloxy)quinoline

Product 1

HCID 214693313-Amino-7-(2-trifluoromethylbenzyloxy)quinoline

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

In ethanol (30 mL) was suspended 3-nitro-7-(2-trifluoromethylbenzyloxy)quinoline (600 mg, 1.72 mmol.), and to the suspension was added platinum oxide (72 mg). Then, catalytic reduction was performed for 3 hours. After the completion of reaction was confirmed, the reaction mixture was filtered over Celite®, and the filtrate was placed under reduced pressure to leave the desired compound as brown oil in the quantitative yield.

Workup

  1. customAfter the completion of reaction
  2. filtrationthe reaction mixture was filtered over Celite®

Sources & evidence

ORD record
ord-ec5422ec689e43a8bdbf528a60d38702
Source dataset
uspto-grants-1997_12
Patent number
US05693651

Reaction notes

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