Pyridinium chloride → HCID 21469456, compound

HRID 1938363Notes

Reaction equation

HRID 1938363 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([C:20]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([O:29]C)[CH:27]=4)[NH:22][CH:21]=3)[CH2:16][CH2:15]2)=[CH:2]1.Cl.N1C=CC=CC=1>N1C=CC=CC=1>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([C:20]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([OH:29])[CH:27]=4)[NH:22][CH:21]=3)[CH2:16][CH2:15]2)=[CH:2]1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 21469374HCID 21469374, compound

Product 1

HCID 21469456HCID 21469456, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 1.6 g of 3-[1-(4-(indol-3-yl)butyl)-4-piperidyl]-5-methoxyindole [which can be prepared according to Example 1], 1.8 g of pyridine hydrochloride and 50 ml of pyridine is boiled for 3 hours. The mixture is cooled, the solvent is evaporated and the residue is worked up in a conventional manner and gives 3-[1-(4-(indol-3-yl)butyl)-4-piperidyl]-5-hydroxyindole, m.p. 178°-180°.

Workup

  1. temperatureThe mixture is cooled
  2. customthe solvent is evaporated

Sources & evidence

ORD record
ord-c1c3eea670ba445297e6d60b6241975e
Source dataset
uspto-grants-1997_12
Patent number
US05693655

Reaction notes

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