Potassium Carbonate → HCID 21469848, compound

HRID 1938633Notes

Reaction equation

HRID 1938633 reaction equation
[OH:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:23][CH2:24][CH2:25][CH2:26][Cl:27]>CC(C)=O>[Cl:27][CH2:26][CH2:25][CH2:24][CH2:23][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 143474-HydroxybenzophenoneHCID 813641-Bromo-4-chlorobutane

Product 1

HCID 21469848HCID 21469848, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Combine 4-hydroxybenzophenone (8 kg, 57.6 mol), potassium carbonate (8 kg, 57.6 mol), and 1-bromo-4-chlorobutane (8.384 kg, 48.9 mol) in acetone (40 L). Heat to reflux. After 20 hours, cool the reaction mixture and filter. Rinse the filter cake with acetone and evaporate the filtrate in vacuo to obtain 4-(4-chlorobutoxy) benzophenone.

Workup

  1. temperatureHeat to reflux
  2. temperaturecool the reaction mixture
  3. filtrationfilter
  4. washRinse the filter cake with acetone
  5. customevaporate the filtrate in vacuo

Sources & evidence

ORD record
ord-15b49d261bcd4b29a61210e72a7b07f1
Source dataset
uspto-grants-1997_12
Patent number
US05693674

Reaction notes

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