Diisopropylaniline → 2-(5-Dodecyl-tetrazol-2-yl)-2-phenyl-N-(2,4,6-trimethoxy-phenyl)-acetamide

HRID 1938699Notes

Reaction equation

HRID 1938699 reaction equation
[CH2:1]([C:13]1[N:14]=[N:15][N:16]([CH:18]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:19]([OH:21])=O)[N:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C(C1N=NN(CC(O)=O)N=1)CCCCCCCCC.[CH3:47][O:48][C:49]1[CH:55]=[C:54]([O:56][CH3:57])[CH:53]=[C:52]([O:58][CH3:59])[C:50]=1[NH2:51].C(C1C=CC=C(C(C)C)C=1N)(C)C>>[CH2:1]([C:13]1[N:14]=[N:15][N:16]([CH:18]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:19]([NH:51][C:50]2[C:52]([O:58][CH3:59])=[CH:53][C:54]([O:56][CH3:57])=[CH:55][C:49]=2[O:48][CH3:47])=[O:21])[N:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

5

Reactant 4

HCID 32484DiisopropylanilineHCID 842712,4,6-TrimethoxyanilineHCID 10523338(+/-)-5-dodecyl-alpha-phenyl-2H-tetrazole-2-acetic acidHCID 214695295-decyl-2H-tetrazole-2-acetic acid

Product 1

HCID 103249302-(5-Dodecyl-tetrazol-2-yl)-2-phenyl-N-(2,4,6-trimethoxy-phenyl)-acetamide

Procedure

When in the general procedure of Example 88 an appropriate amount of (±)-5-dodecyl-α-phenyl-2H-tetrazole-2-acetic acid was substituted for 5-decyl-2H-tetrazole-2-acetic acid and 2,4,6-trimethoxyaniline was substituted for 2,6-diisopropylaniline, the title compound was obtained, mp 141°-145° C.

Sources & evidence

ORD record
ord-11abb5eb3756435e86dbfacf96aac55f
Source dataset
uspto-grants-1997_12
Patent number
US05693657

Reaction notes

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