Cysteamine Hydrochloride → HCID 131718855, compound

HRID 1938900Notes

Reaction equation

HRID 1938900 reaction equation
[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4]([Cl:6])=[O:5].Cl.[NH2:11][CH2:12][CH2:13][SH:14]>CCOCC>[ClH:6].[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4](=[O:5])[S:14][CH2:13][CH2:12][NH2:11]

Participants

4

Reactant 2

HCID 9082Cysteamine HydrochlorideHCID 109207893,4,4-Trifluoro-3-butenoyl chloride

Product 1

HCID 131718855HCID 131718855, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 3,4,4-trifluoro-3-butenoyl chloride (2.5 g, 0.0158 mole) and 2-aminoethanethiol hydrochloride (1.14 g, 0.010 mole) is slowly heated to reflux for 15 min. The mixture is cooled to room temperature and treated with dry ether and filtered. The product is recrystallized from absolute ethanol to give 0.8 g of the title compound as a off-white solid, a 34% yield. m.p. 95°-115° C.

Workup

  1. temperatureis slowly heated
  2. temperatureto reflux for 15 min
  3. filtrationfiltered
  4. customThe product is recrystallized from absolute ethanol

Sources & evidence

ORD record
ord-a1a3d5569b8a4198b671a31576eb2ba6
Source dataset
uspto-grants-1997_12
Patent number
US05693865

Reaction notes

Loading…