Ammonia → N-(3,4,4-trifluoro-3-butenyl)ethanediamide

HRID 1938902Notes

Reaction equation

HRID 1938902 reaction equation
O=[C:2]([NH:9][C:10](=[O:15])[C:11](OC)=[O:12])[CH2:3][C:4]([F:8])=[C:5]([F:7])[F:6].[NH3:16]>CO>[F:8][C:4](=[C:5]([F:7])[F:6])[CH2:3][CH2:2][NH:9][C:10](=[O:15])[C:11]([NH2:16])=[O:12]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86748464Oxo[(3,4,4-trifluoro-3-butenyl)amino]oxoacetic acid, methyl ester

Product 1

HCID 15239196N-(3,4,4-trifluoro-3-butenyl)ethanediamideYield 68%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of Compound 142 (5.0 g, 0.0237 mole) in methanol (50 mL) is saturated with dry gaseous ammonia at room temperature. The precipitate is filtered, washed with methanol and dried to give 3.16 g of the title compound as a white solid, a 68% yield. m.p. 190°-220° C.

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed with methanol
  3. customdried

Sources & evidence

ORD record
ord-e4325b4767114a76b0a8e7feac1d924a
Source dataset
uspto-grants-1997_12
Patent number
US05693865

Reaction notes

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