Potassium Carbonate → HCID 21223285, compound

HRID 1939141Notes

Reaction equation

HRID 1939141 reaction equation
C([O:4][CH2:5][C:6]1[O:11][CH2:10][N:9]([C:12]([CH3:20])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[C:8](=[O:21])[C:7]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:4][CH2:5][C:6]1[O:11][CH2:10][N:9]([C:12]([CH3:13])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:20])[C:8](=[O:21])[C:7]=1[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 15405503HCID 15405503, compound

Product 1

HCID 21223285HCID 21223285, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-Acetyloxymethyl-3-(1-methyl-1-phenylethyl)-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 66, 4.99 g) was dissolved in methanol (55 ml), and an aqueous solution (14 ml) of potassium carbonate (1.3 g) was added slowly thereto. This mixture was allowed to react by stirring at room temperature for one hour. Methanol was removed by evaporation, and the residue was acidified with 2N hydrochloric acid, and extracted with ethyl acetate. The organic layer was rinsed with saturated saline solution, and dried with magnesium sulfate to afford the captioned product (4.0 g, yield 91%).

Workup

  1. customto react
  2. customMethanol was removed by evaporation
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was rinsed with saturated saline solution
  5. dry with materialdried with magnesium sulfate

Sources & evidence

ORD record
ord-86239cd0733a416ba109759d0015cbf1
Source dataset
uspto-grants-1997_12
Patent number
US05696054

Reaction notes

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