HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylbenzoyl chloride → N-[4-[(5,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenyl]-2-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylbenzoyl chloride | HCID 70276 | — |
| Reactant | 4-(4-Aminobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine | HCID 21467142 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[4-[(5,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenyl]-2-methylbenzamide | HCID 11269308 | — |
Reaction Steps
As described for Example 1, 4-(4-aminobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine (0.001 ml) is reacted with 2-methylbenzoyl chloride in dichloromethane to give the product. Crystallization from ethyl acetate-hexane gives crystals, m.p. 181°-182° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696112 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-32dda61729ce494cbafb37ecefc37d3b |
| Source note | uspto-grants-1997_12 |