Pivaloyl chloride → HCID 13154251, compound

HRID 1939243Notes

Reaction equation

HRID 1939243 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[N:3]=1.[C:9](Cl)(=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11]>CCN(CC)CC>[F:8][C:4]1[N:3]=[C:2]([NH:1][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 62493Pivaloyl chlorideHCID 27613996-Fluoropyridin-2-amine

Product 1

HCID 13154251HCID 13154251, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A solution of 2-amino-6-fluoropyridine (4.2 g) in CH2C2 (100 ml) was treated with Et3N (8 ml) and pivaloyl chloride (5 ml) at 0° C. to room temperature overnight. The reaction mixture was washed with water (50 ml), 2N H2SO4 (50 ml), water (50 ml) and dried (Na2SO4). Evaporation of the solvent afforded 6-fluoro-2-pivaloylaminopyridine (6 g).

Workup

  1. washThe reaction mixture was washed with water (50 ml), 2N H2SO4 (50 ml), water (50 ml)
  2. dry with materialdried (Na2SO4)
  3. customEvaporation of the solvent

Sources & evidence

ORD record
ord-1d6f29f290ba4b55a1e0330466da3fc3
Source dataset
uspto-grants-1997_12
Patent number
US05696129

Reaction notes

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