反应详情

A solution of methyl-6-amino-2-methoxypyridine-3-carboxylate (0.4 g) in acetic acid (10 ml) was treated with a solution of Cl2 (0.19 g) in HOAc (4 ml) at room temperature for 3 h. The AcOH was removed by rotary evaporation and the residue treated with aqueous NaHCO3 (50 mL) and the product extracted into EtOAc (100 mL). Evaporation afforded methyl-6-amino-5-chloro-2-methoxypyridine-3-carboxylate (0.32 g).

1. customThe AcOH was removed by rotary evaporation
2. additionthe residue treated with aqueous NaHCO3 (50 mL)
3. extractionthe product extracted into EtOAc (100 mL)
4. customEvaporation