HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → Methyl-6-amino-5-chloro-2-methoxypyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Methyl 6-amino-2-methoxynicotinate | HCID 11159681 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Methyl-6-amino-5-chloro-2-methoxypyridine-3-carboxylate | HCID 22101798 | 67.3% |
Reaction Steps
A solution of methyl-6-amino-2-methoxypyridine-3-carboxylate (0.4 g) in acetic acid (10 ml) was treated with a solution of Cl2 (0.19 g) in HOAc (4 ml) at room temperature for 3 h. The AcOH was removed by rotary evaporation and the residue treated with aqueous NaHCO3 (50 mL) and the product extracted into EtOAc (100 mL). Evaporation afforded methyl-6-amino-5-chloro-2-methoxypyridine-3-carboxylate (0.32 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696129 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-8ee492bec8e14475aa6f0e1f353636af |
| Source note | uspto-grants-1997_12 |