Water → 6-Amino-5-chloro-2-methoxypyridine-3-carboxylic Acid

HRID 1939246Notes

Reaction equation

HRID 1939246 reaction equation
C[O:2][C:3]([C:5]1[C:6]([O:13][CH3:14])=[N:7][C:8]([NH2:12])=[C:9]([Cl:11])[CH:10]=1)=[O:4].[OH-].[Na+].O>CO>[NH2:12][C:8]1[N:7]=[C:6]([O:13][CH3:14])[C:5]([C:3]([OH:4])=[O:2])=[CH:10][C:9]=1[Cl:11]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 22101798Methyl-6-amino-5-chloro-2-methoxypyridine-3-carboxylate

Product 1

HCID 222626616-Amino-5-chloro-2-methoxypyridine-3-carboxylic Acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl-6-amino-5-chloro-2-methoxypyridine-3-carboxylate (0.32 g) in MeOH (5 mL) was treated with 2.5N NaOH (0.6 mL) and H2O (5 mL) and the reaction stirred at room temperature until the reaction was complete by TLC. The MeOH was removed by rotary evaporation and the residue carefully acidified with 5N HCl to give the title compound which was collected and dried (0.15 g).

Workup

  1. customThe MeOH was removed by rotary evaporation

Sources & evidence

ORD record
ord-b3fbf530bcf84046ac8a8bfd9fea5403
Source dataset
uspto-grants-1997_12
Patent number
US05696129

Reaction notes

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