HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-Amino-5-chloro-2-methoxypyridine-3-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl-6-amino-5-chloro-2-methoxypyridine-3-carboxylate | HCID 22101798 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Amino-5-chloro-2-methoxypyridine-3-carboxylic Acid | HCID 22262661 | — |
Reaction Steps
A solution of methyl-6-amino-5-chloro-2-methoxypyridine-3-carboxylate (0.32 g) in MeOH (5 mL) was treated with 2.5N NaOH (0.6 mL) and H2O (5 mL) and the reaction stirred at room temperature until the reaction was complete by TLC. The MeOH was removed by rotary evaporation and the residue carefully acidified with 5N HCl to give the title compound which was collected and dried (0.15 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696129 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-b3fbf530bcf84046ac8a8bfd9fea5403 |
| Source note | uspto-grants-1997_12 |