Sodium Bicarbonate → HCID 21467258, compound

HRID 1939247Notes

Reaction equation

HRID 1939247 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](F)[C:5]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[CH:4][CH:3]=1.[CH3:16][C:17](C)([O-:19])C.[K+].C([O-])(O)=O.[Na+]>CCO>[NH2:1][C:2]1[N:7]=[C:6]([O:19][CH2:17][CH3:16])[C:5]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 516892Sodium BicarbonateHCID 21467261HCID 21467261, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 21467258HCID 21467258, compoundYield 76.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

tert-Butyl 6-amino-2-fluoropyridine-3-carboxylate (0.7 g, 0.0033 mol) in EtOH (25 ml) was treated with potassium tert-butoxide (0.39 g, 0.0035mol) and the mixture was heated under reflux overnight. After cooling to room temperature, saturated NaHCO3 solution was added and the precipitated solid was collected by filtration and dried/n vacuo to give tert-butyl 6-amino-2-ethoxypyridine-3-carboxylate(0.6 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux overnight
  3. filtrationthe precipitated solid was collected by filtration
  4. customdried/n vacuo

Sources & evidence

ORD record
ord-5c5b5b8d97ed442d9fe91ac98da56d72
Source dataset
uspto-grants-1997_12
Patent number
US05696129

Reaction notes

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