Dichloromethane → HCID 86751704, compound

HRID 1939249Notes

Reaction equation

HRID 1939249 reaction equation
[Br:1][C:2]1[C:7]([O:8][CH2:9][C:10]#C)=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[CH2:13]Cl>>[Br:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[CH:13]=[C:9]([CH3:10])[O:8][C:7]=12

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 21467243HCID 21467243, compound

Product 1

HCID 86751704HCID 86751704, compoundYield 46%

Procedure

2-Bromo-3-propargyloxypyridine (9.4 g) was heated under reflux under nitrogen in dichloromethane (100 ml) for 64 hours, then the solvent was removed in vacuo and the residue purified by column chromatography on silica using dichloromethane as eluant to give 7-bromo-2-methylfurano[2,3-c]pyridine as a tan solid (4.3 g, 46%).

Workup

  1. customthe solvent was removed in vacuo
  2. customthe residue purified by column chromatography on silica

Sources & evidence

ORD record
ord-6fc1cdd28b5b4a16915ad2a725b84b42
Source dataset
uspto-grants-1997_12
Patent number
US05696129

Reaction notes

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