alpha-Naphthyl isocyanate → HCID 23209071, compound

HRID 1939279Notes

Reaction equation

HRID 1939279 reaction equation
[OH:1][C:2]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:3]=1[NH2:4].[C:13]1([N:23]=[C:24]=[O:25])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1>C1(C)C=CC=CC=1>[C:13]1([NH:23][C:24]([NH:4][C:3]2[CH:5]=[C:6]([C:9]([F:10])([F:11])[F:12])[CH:7]=[CH:8][C:2]=2[OH:1])=[O:25])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 66589alpha-Naphthyl isocyanateHCID 1202462-Amino-4-(trifluoromethyl)phenol

Product 1

HCID 23209071HCID 23209071, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

2-hydroxy-5-(trifluoromethyl)aniline (0.12 g, 0.7 mmol) in toluene (3 ml) was added to a solution of alpha-naphthyl isocyanate (0.11 g, 0.7 mmol) in toluene (3 ml). The reaction was stirred at RT overnight and the product filtered off. 0.17 g (72%) of the title compound was isolated. M.p. 205°-207° C.

Workup

  1. filtrationthe product filtered off

Sources & evidence

ORD record
ord-10d93b7cf48a4e8686b7545bf140e9d0
Source dataset
uspto-grants-1997_12
Patent number
US05696138

Reaction notes

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