Methanone, (3-aminophenyl)phenyl- → N-(3-benzoylphenyl)-N'-(2-methoxy-5-chlorophenyl) urea

HRID 1939285Notes

Reaction equation

HRID 1939285 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([N:8]=[C:9]=[O:10])[CH:7]=1.[NH2:13][C:14]1[CH:15]=[C:16]([CH:25]=[CH:26][CH:27]=1)[C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:18]>C1(C)C=CC=CC=1>[C:17]([C:16]1[CH:15]=[C:14]([NH:13][C:9]([NH:8][C:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[O:11][CH3:12])=[O:10])[CH:27]=[CH:26][CH:25]=1)(=[O:18])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 17817Methanone, (3-aminophenyl)phenyl-HCID 1440094-Chloro-2-isocyanato-1-methoxybenzene

Product 1

HCID 53686550N-(3-benzoylphenyl)-N'-(2-methoxy-5-chlorophenyl) ureaYield 92.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 5-chloro-2-methoxyphenyl isocyanate (1.00 g, 5.4 mmol) and 3-aminobenzophenone (1.29 g, 6.5 mmol) was stirred in toluene (20 ml) for two days. The reaction was filtered and the filter cake washed with toluene. 1.9 g of the title compound was isolated.

Workup

  1. filtrationThe reaction was filtered
  2. washthe filter cake washed with toluene

Sources & evidence

ORD record
ord-cd922a6dd0144ddf8addaae32b83b2f4
Source dataset
uspto-grants-1997_12
Patent number
US05696138

Reaction notes

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