反应详情

N-(4-Phenoxybutyl)-N'-3-pyridylthiourea (1.41 g) was dissolved in acetonitrile (10 ml), and cyanamide (400 mg), N,N'dicyclohexylcarbodiimide (1.95 g) and triethylamine (0.08 ml) were added. The mixture was stirred for 3 days at room temperature, when it was filtered, washed with acetonitrile, and ether to yield a solid mixture of the crude product and N,N'-dicyclohexylthiourea. The pure compound was obtained by extracting the mixture with 0.5N hydrochloric acid (16 ml), filtering and re-precipitation by addition of 9N sodium hydroxide to the filtrate.

1. filtrationwhen it was filtered
2. washwashed with acetonitrile, and ether
3. customto yield
4. customThe pure compound was obtained
5. extractionby extracting the mixture with 0.5N hydrochloric acid (16 ml)
6. filtrationfiltering
7. customre-precipitation
8. additionby addition of 9N sodium hydroxide to the filtrate