Phosphorus oxychloride → HCID 15284102, compound

HRID 1939634Notes

Reaction equation

HRID 1939634 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[C:10]2[C:19]3[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=3[NH:13][C:12](=O)[N:11]2[CH:21]=1.O=P(Cl)(Cl)[Cl:24]>>[Cl:24][C:12]1[N:11]2[CH:21]=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])[N:9]=[C:10]2[C:19]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=2[N:13]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 152840972-(2-Fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one

Product 1

HCID 15284102HCID 15284102, compound

Procedure

To 50 mL of POCl3 was added 2-(2-Fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one (600 mg) and the resultant mixture was refluxed for 48 h. The mixture was then cooled and the POCl3 was removed in vacuo. To the residue was added 20 mL of water and the pH adjusted to 7 with ammonium hydroxide. After cooling, the precipitated solid was collected to yield 5-Chloro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (Compound 30), m.p. 175°-176° C.

Workup

  1. temperatureThe mixture was then cooled
  2. customthe POCl3 was removed in vacuo
  3. additionTo the residue was added 20 mL of water
  4. temperatureAfter cooling
  5. customthe precipitated solid was collected

Sources & evidence

ORD record
ord-4b7e5b2586554b069646f99c41431609
Source dataset
uspto-grants-1997_12
Patent number
US05696260

Reaction notes

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