HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → alpha-(2-Bromoethyl)-3,4-dichlorophenylacetic acid chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | alpha-(2-Bromoethyl)-3,4-dichlorophenylacetic acid | HCID 18936610 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | alpha-(2-Bromoethyl)-3,4-dichlorophenylacetic acid chloride | HCID 54519315 | — |
Reaction Steps
Dissolve the product of Step 2 (8.1 g, 25.96 mmoles) in 20 ml. of dry CH2Cl2. Add oxalyl chloride (8.1 g, 62.3 mmoles), followed by 50 μl of dry DMF and heat the solution to reflux for 3 h. Cool the solution to room temperature and remove the solvent and excess reagent using reduced pressure. Yield: 8.2 g (IR: 1785 cm- 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696267 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-389369ba39704ea288e3c1738639a2b8 |
| Source note | uspto-grants-1997_12 |