HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 4-(4-chlorophenyl)-4-hydroxy-cyclohexanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 4-oxocyclohexanecarboxylate | HCID 317638 | — |
| Reactant | HCID 178478983 | HCID 178478983 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Ethyl 4-(4-chlorophenyl)-4-hydroxy-cyclohexanecarboxylate | HCID 21465094 | — |
Reaction Steps
Slowly add 4-chlorophenylmagnesium chloride (5.9 mL of 1M solution) to a solution of ethyl 4-oxo-cyclohexanecarboxylate (1.0 g) in Et2O at 0° C. After 1 h, pour the reaction mixture into 1N HCl and extract with Et2O. Separate the organic layer, wash with water, brine and concentrate to give ethyl 4-(4-chlorophenyl)-4-hydroxy-cyclohexanecarboxylate (1.75 g) which is used without purification in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05698548 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-10cab5fff31b41b083f636b97614c2d7 |
| Source note | uspto-grants-1997_12 |