HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 4-(4-Chlorophenyl)-cyclohex-3-enecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ethyl 4-(4-chlorophenyl)-4-hydroxy-cyclohexanecarboxylate | HCID 21465094 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(4-Chlorophenyl)-cyclohex-3-enecarboxylic acid | HCID 21465099 | 92.8% |
Reaction Steps
Dissolve the product (1.75 g) from STEP 1 in THF (100 mL), treat with 40% H2SO4 (25 mL) and heat the reaction mixture at reflux for 5.5 h. Remove most of the solvent in vacuo, dilute the reaction mixture with water and extract with Et2O. Separate the organic layer and concentrate to give 4-(4-chlorophenyl)-cyclohex-3-enecarboxylic acid (1.36 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05698548 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-c2aa203d1a73445b97568eeac8d28110 |
| Source note | uspto-grants-1997_12 |