反应详情

Dissolve the product (1.75 g) from STEP 1 in THF (100 mL), treat with 40% H2SO4 (25 mL) and heat the reaction mixture at reflux for 5.5 h. Remove most of the solvent in vacuo, dilute the reaction mixture with water and extract with Et2O. Separate the organic layer and concentrate to give 4-(4-chlorophenyl)-cyclohex-3-enecarboxylic acid (1.36 g).

1. temperatureheat the reaction mixture
2. temperatureat reflux for 5.5 h
3. customRemove most of the solvent in vacuo
4. additiondilute the reaction mixture with water
5. extractionextract with Et2O
6. customSeparate the organic layer
7. concentrationconcentrate