Hydrochloric Acid → HCID 131720359, compound

Participants

Reaction Conditions

Reaction Steps

A stirred solution of 50 (1.19 g, 2.56 mmol) is cooled to 0° C. and treated with HCl gas until saturation. The mixture is stirred at 0° C. for 30 min and the solvent is removed in vacuo to give 51 (1.0 g, 97%, mixture of 2 diastereomers of ketone form and 2 diastereomers of hydrate form, 3:1 ratio of diastereomers and 4:1 ratio of hydrate to ketone) as a white solid.

Provenance & Evidence