Hydrochloric Acid → HCID 131720359, compound

HRID 1940045Notes

Reaction equation

CC(C)(OC(N[C@H](C([N:14]1[CH2:31][CH2:30][CH2:29][C@H:15]1[C:16]([NH:18][CH:19]([CH:26]([CH3:28])[CH3:27])[C:20](=[O:25])[C:21]([F:24])([F:23])[F:22])=[O:17])=O)C(C)C)=O)C.[ClH:33]>>[ClH:33].[NH2:18][C@H:19]([C:20]([N:18]([CH:19]([CH:26]([CH3:27])[CH3:28])[C:20](=[O:25])[C:21]([F:22])([F:23])[F:24])[C:16](=[O:17])[C@@H:15]1[CH2:29][CH2:30][CH2:31][NH:14]1)=[O:25])[CH:26]([CH3:28])[CH3:27]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 10389762HCID 10389762, compound

Product 1

HCID 131720359HCID 131720359, compoundYield 97%

Conditions

Temperature: 0 °C

Procedure

A stirred solution of 50 (1.19 g, 2.56 mmol) is cooled to 0° C. and treated with HCl gas until saturation. The mixture is stirred at 0° C. for 30 min and the solvent is removed in vacuo to give 51 (1.0 g, 97%, mixture of 2 diastereomers of ketone form and 2 diastereomers of hydrate form, 3:1 ratio of diastereomers and 4:1 ratio of hydrate to ketone) as a white solid.

Workup

customthe solvent is removed in vacuo

Sources & evidence

ORD record: ord-ccec85846fe845238b4e8c77f6c8fbd0
Source dataset: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05698523

Reaction notes

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