1-Bromo-2-methylpropane → HCID 21465915, compound

Participants

Reaction Steps

To a solution of 5-(2-chlorophenyl)-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one (2.8 g) and isobutyl bromide (2.24 ml) in dimethylformamide (20 ml) was added sodium hydride (0.82 g, 60% oil) at 0° C. The mixture was stirred for 4 hours at room temperature, then the solvent was distilled off, and the residue was purified by means of a silica-gel column chromatography to give 2.98 g of colorless crystals, m.p. 139°-140° C.

Provenance & Evidence