1-Bromo-2-methylpropane → HCID 21465915, compound

HRID 1940193Notes

Reaction equation

HRID 1940193 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][C:11](=[O:19])[CH2:10][CH2:9]1.[CH2:20](Br)[CH:21]([CH3:23])[CH3:22].[H-].[Na+]>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([CH2:20][CH:21]([CH3:23])[CH3:22])[C:11](=[O:19])[CH2:10][CH2:9]1

Participants

5

Reactant 3

HCID 65551-Bromo-2-methylpropaneHCID 24758Sodium hydrideHCID 21465882HCID 21465882, compound

Product 1

HCID 21465915HCID 21465915, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 5-(2-chlorophenyl)-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one (2.8 g) and isobutyl bromide (2.24 ml) in dimethylformamide (20 ml) was added sodium hydride (0.82 g, 60% oil) at 0° C. The mixture was stirred for 4 hours at room temperature, then the solvent was distilled off, and the residue was purified by means of a silica-gel column chromatography to give 2.98 g of colorless crystals, m.p. 139°-140° C.

Workup

  1. distillationthe solvent was distilled off
  2. customthe residue was purified by means of a silica-gel column chromatography

Sources & evidence

ORD record
ord-5882c19099914a46973e2064755f7738
Source dataset
uspto-grants-1997_12
Patent number
US05698691

Reaction notes

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