Oxalyl chloride → 3-Cyclopentylthio-4-methoxybenzoyl chloride

HRID 1940324Notes

Reaction equation

HRID 1940324 reaction equation
[CH:1]1([S:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[C:10](O)=[O:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)(=O)C([Cl:21])=O>ClCCl>[CH:1]1([S:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[C:10]([Cl:21])=[O:11])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 211878613-(Cyclopentylthio)-4-methoxybenzoic acid

Product 1

HCID 211879163-Cyclopentylthio-4-methoxybenzoyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 3-cyclopentylthio-4-methoxybenzoic acid (9 g; that is prepared as described in Reference Example 46) in dry dichloromethane (90 mL) under nitrogen is treated with oxalyl chloride (6.2 mL). After stirring at room temperature for 2 hours, the mixture is evaporated and dried under high vacuum, to give 3-cyclopentylthio-4-methoxybenzoyl chloride.

Workup

  1. customthat is prepared
  2. customthe mixture is evaporated
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-60138baca8fd4857a7a7c448cc8a6511
Source dataset
uspto-grants-1997_12
Patent number
US05698711

Reaction notes

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