Hydrochloric Acid → HCID 22095094, compound

Participants

Reaction Steps

N,N-bis(2,3-dihydroxypropyl)-1-hydroxy-2,4,6-triiodobenzene-3,5-dicarboxylic acid diamide (13.1 g, 40 mmol) was dissolved in water (160 mL) and pH was adjusted to 3.9 using aqueous HCl. To this solution, NaICl2 (42.6 g, 50.3%, 40 mmol) was added dropwise during a period of 30 minutes. After standing overnight, the reaction mixture was evaporated. The product was purified by preparative HPLC (RP-18, CH3CN: H2O 15:85, 1% TFA). Yield 22.3 g (79%).

Provenance & Evidence