Hydrochloric Acid → HCID 22095094, compound

HRID 1940463Notes

Reaction equation

HRID 1940463 reaction equation
[OH:1][CH:2]([CH2:25][OH:26])[CH2:3][N:4](CC(O)CO)[C:5]([C:7]1[C:8]([I:19])=[C:9]([OH:18])[C:10]([I:17])=[C:11]([C:14]([NH2:16])=[O:15])[C:12]=1[I:13])=[O:6].Cl>O>[OH:1][CH:2]([CH2:25][OH:26])[CH2:3][NH:4][C:5]([C:7]1[C:8]([I:19])=[C:9]([OH:18])[C:10]([I:17])=[C:11]([C:14]([NH2:16])=[O:15])[C:12]=1[I:13])=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86751753HCID 86751753, compound

Product 1

HCID 22095094HCID 22095094, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N,N-bis(2,3-dihydroxypropyl)-1-hydroxy-2,4,6-triiodobenzene-3,5-dicarboxylic acid diamide (13.1 g, 40 mmol) was dissolved in water (160 mL) and pH was adjusted to 3.9 using aqueous HCl. To this solution, NaICl2 (42.6 g, 50.3%, 40 mmol) was added dropwise during a period of 30 minutes. After standing overnight, the reaction mixture was evaporated. The product was purified by preparative HPLC (RP-18, CH3CN: H2O 15:85, 1% TFA). Yield 22.3 g (79%).

Workup

  1. customthe reaction mixture was evaporated
  2. customThe product was purified by preparative HPLC (RP-18, CH3CN: H2O 15:85, 1% TFA)

Sources & evidence

ORD record
ord-4b96aecbc60848dfb0ee3946eb6e8367
Source dataset
uspto-grants-1997_12
Patent number
US05700448

Reaction notes

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