Lawesson's reagent → HCID 53810519, compound

HRID 1940506Notes

Reaction equation

HRID 1940506 reaction equation
COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:10])=CC=1.[NH2:23][N:24]1[C:29]([C:30]([F:33])([F:32])[F:31])=[CH:28][C:27](=O)[N:26]([C:35]2[CH:40]=[C:39]([CH:41]=[N:42][O:43][CH3:44])[C:38]([Cl:45])=[CH:37][C:36]=2[F:46])[C:25]1=[O:47]>C1(C)C=CC=CC=1>[NH2:23][N:24]1[C:29]([C:30]([F:33])([F:32])[F:31])=[CH:28][C:27](=[S:10])[N:26]([C:35]2[CH:40]=[C:39]([CH:41]=[N:42][O:43][CH3:44])[C:38]([Cl:45])=[CH:37][C:36]=2[F:46])[C:25]1=[O:47]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 53836288HCID 53836288, compound

Product 1

HCID 53810519HCID 53810519, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3.4 g of Lawesson's reagent were added to a solution of 1-amino-3-(4-chloro-2-fluoro-5-methoxyiminomethylphenyl)-2,4-dioxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine (3.8 g) in 100 ml of toluene. After refluxing for 12 hours, the solvent was removed and the crude product obtained was purified by chromatography. Yield: 2.2 g; m.p.: 172°-174° C.

Workup

  1. temperatureAfter refluxing for 12 hours
  2. customthe solvent was removed

Sources & evidence

ORD record
ord-4e3dd8fecf9941a0b5b09d56ebd3304e
Source dataset
uspto-grants-1997_12
Patent number
US05700805

Reaction notes

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