HCID 21462927, compound → HCID 21462925, compound

HRID 1940581Notes

Reaction equation

HRID 1940581 reaction equation
[CH3:1][O:2][C:3]1[CH:37]=[CH:36][CH:35]=[CH:34][C:4]=1[CH2:5][N:6]1[C:11](=[O:12])[C:10]([C:13]([OH:15])=[O:14])=[C:9]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[C:8]2[O:24][C:25]3[CH:30]=[C:29]([N+:31]([O-])=O)[CH:28]=[CH:27][C:26]=3[C:7]1=2>CO.[Ni]>[NH2:31][C:29]1[CH:28]=[CH:27][C:26]2[C:7]3[N:6]([CH2:5][C:4]4[CH:34]=[CH:35][CH:36]=[CH:37][C:3]=4[O:2][CH3:1])[C:11](=[O:12])[C:10]([C:13]([OH:15])=[O:14])=[C:9]([C:16]4[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=4)[C:8]=3[O:24][C:25]=2[CH:30]=1

Participants

4

Reactant 1

HCID 21462927HCID 21462927, compound

Product 1

HCID 21462925HCID 21462925, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A solution of 1 g of 1,2-dihydro-1-(2-methoxybenzyl)-4-(4-methoxyphenyl)-2-oxo-7-nitrobenzofuro[3,2-b]pyridine-3-carboxylic acid, m.p. 245°, prepared analogously to Examples 1 and 2, in 25 ml of methanol is hydrogenated to completion on 1 g of Raney nickel at normal pressure and 20°. The mixture is filtered, the solvent is removed and 7-amino-1,2-dihydro-1-(2-methoxybenzyl)-4-(4-methoxyphenyl)-2-oxobenzofuro[3,2-b]pyridine-3-carboxylic acid, m.p. 268°, is obtained.

Workup

  1. filtrationThe mixture is filtered
  2. customthe solvent is removed

Sources & evidence

ORD record
ord-60622554f65b4971b71b2ce844160d85
Source dataset
uspto-grants-1997_12
Patent number
US05700807

Reaction notes

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