Cesium carbonate → HCID 21462930, compound

HRID 1940585Notes

Reaction equation

HRID 1940585 reaction equation
[S:1](Cl)([CH3:4])(=[O:3])=[O:2].C(=O)([O-])[O-].[Cs+].[Cs+].[NH2:12][C:13]1[CH:18]=[CH:17][C:16]2[C:19]3[N:20]([CH2:40][C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=4[O:47][CH3:48])[C:21](=[O:39])[C:22]([C:34]([O:36][CH2:37][CH3:38])=[O:35])=[C:23]([C:26]4[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=4)[C:24]=3[O:25][C:15]=2[CH:14]=1>CN(C=O)C>[CH3:4][S:1]([NH:12][C:13]1[CH:18]=[CH:17][C:16]2[C:19]3[N:20]([CH2:40][C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=4[O:47][CH3:48])[C:21](=[O:39])[C:22]([C:34]([O:36][CH2:37][CH3:38])=[O:35])=[C:23]([C:26]4[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=4)[C:24]=3[O:25][C:15]=2[CH:14]=1)(=[O:3])=[O:2]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 31297Methanesulfonyl chlorideHCID 21462918HCID 21462918, compound

Product 1

HCID 21462930HCID 21462930, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Equimolar quantities of mesyl chloride and cesium carbonate are added to a solution of ethyl 7-amino-1,2-dihydro-1-(2-methoxybenzyl)-4-(4-methoxyphenyl)-2-oxobenzofuro[3,2-b]pyridine-3-carboxylate in DMF and the mixture is stirred for one hour. After customary working up, ethyl 7-methylsulphonylamino-1,2-dihydro-1-(2-methoxybenzyl)-4-(4-methoxyphenyl)-2-oxobenzofuro-[3,2-b]pyridine-3-carboxylate is obtained.

Sources & evidence

ORD record
ord-af6936ebaf414514b81289643eac9b45
Source dataset
uspto-grants-1997_12
Patent number
US05700807

Reaction notes

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