HCID 54441057, compound → HCID 67621078, compound

HRID 1940595Notes

Reaction equation

HRID 1940595 reaction equation
[C:1]([O:5][C:6](=[O:25])[N:7]([C:13]1[C:21]2[O:20][CH2:19][CH2:18][C:17]=2[CH:16]=[C:15]([N+:22]([O-])=O)[CH:14]=1)[CH2:8][CH2:9][N:10]([CH3:12])[CH3:11])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:25])[N:7]([C:13]1[C:21]2[O:20][CH2:19][CH2:18][C:17]=2[CH:16]=[C:15]([NH2:22])[CH:14]=1)[CH2:8][CH2:9][N:10]([CH3:12])[CH3:11])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 54441057HCID 54441057, compound

Product 1

HCID 67621078HCID 67621078, compoundYield 73.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 5-nitro-2,3-dihydrobenzofuran-7-yl)-(2-dimethylaminoethyl)carbamic acid tert-butyl ester (D6) (387 mg) in ethanol (50 ml) was hydrogenated over 10% palladium on charcoal for 2 h at atmospheric pressure and room temperature. The catalyst was removed by filtration and the flitrate evaporated under reduced pressure to give the title compound as a brown oil (260 mg, 73%).

Workup

  1. customThe catalyst was removed by filtration
  2. customthe flitrate evaporated under reduced pressure

Sources & evidence

ORD record
ord-f1a53a81635642f79282881b774bbdcd
Source dataset
uspto-grants-1997_12
Patent number
US05700818

Reaction notes

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