HCID 21463514, compound → HCID 21463565, compound

HRID 1940635Notes

Reaction equation

HRID 1940635 reaction equation
[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][C:11]#[N:12])[C:5]=1[Cl:13])#[N:2].Cl.N[C:16]1[C:21]([F:22])=[C:20]([F:23])[CH:19]=[CH:18][C:17]=1[SH:24]>>[F:22][C:21]1[C:16]2[N:2]=[C:1]([CH2:3][C:4]3[C:5]([Cl:13])=[C:6]([CH2:10][C:11]#[N:12])[CH:7]=[CH:8][CH:9]=3)[S:24][C:17]=2[CH:18]=[CH:19][C:20]=1[F:23]

Participants

3

Reactant 2

HCID 21463514HCID 21463514, compoundHCID 56997307HCID 56997307, compound

Product 1

HCID 21463565HCID 21463565, compoundYield 20%

Procedure

The procedure of Example 22-i) was repeated using 1,3-biscyanomethyl-2-chlorobenzene (870 mg, 4.4 mmol) and 2-amino-3,4-difluorothiophenol hydrochloride (956 mg, 4.8 mmol) and the resultant product was recrystallized from ethyl acetate-hexane to give 3-[(4,5-difluorobenzothiazol-2-yl)methyl]-2-chlorophenylacetonitrile (295 mg, 20%) as a colorless powder.

Workup

  1. customthe resultant product was recrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-d0f94fb21e6640ef99944bd8beba35a5
Source dataset
uspto-grants-1997_12
Patent number
US05700819

Reaction notes

Loading…