反应详情

5-(4-acetoxymethyl-3-chlorophenyl)-3-(2-chloro-6-fluorophenyl)-1-methyl-1H-1,2,4-triazole (11.1 g) is dissolved in a mixed solvent of ethanol (50 ml) and water (20 ml), added with sodium hydroxide (2.3 g) and heated under reflux for 1 hour with stirring. After cooling to room temperature, the reaction mixture is added with ethyl acetate and washed with water. Then, it is dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain crude solid. The crude solid is washed with mixed solvent of hexane-ethanol to give 6.7 g of desired compound (melting point: 111°-113° C.).

1. temperatureheated
2. temperatureunder reflux for 1 hour
3. washwashed with water
4. dry with materialThen, it is dried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customto obtain crude solid
7. washThe crude solid is washed with mixed solvent of hexane-ethanol